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Updated: Jul 20, 2026

Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers
10:08

Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers

Published on: July 25, 2012

エンタルピー対エントロピー駆動によるビスホスフォネートのファルネシル二酸化酸塩合成酵素への結合

Fenglin Yin1, Rong Cao, Amanda Goddard

  • 1Department of Biophysics, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, Illinois 61801, USA.

Journal of the American Chemical Society
|March 16, 2006
PubMed
まとめ

私たちは,6つのビスホスフォナートが,異熱滴定カロリメトリを用いて,ファルネシル二酸化リン酸合成酵素 (FPPS) に結合する方法を研究しました. 結合は,いくつかの化合物ではエンタルピー駆動,他の化合物ではエントロピー駆動で,FPPSの抑制と潜在的な薬物開発に影響を与えます.

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