会議要約から,ランダム化対照試験のための全長ジャーナル記事への移行
Mustafa Toma1, Finlay A McAlister, Liza Bialy
1The Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, Canada.
JAMA
|March 16, 2006
まとめ
科学的会合で発表される遅発のランダム化対照試験 (RCT) は,より大きく,より早く公表され,好ましい結果を報告する可能性が低い. しかし,抽象版と完全版の発表結果の間の不一致は,すべてのRCTに共通しています.
科学分野:
- 心臓病学 心臓病学
- クリニック・トライアル 臨床試験
- 科学的出版物 科学的出版物
背景:
- 科学会議のプレゼンテーションは,公表された研究と異なる場合があります.
- 公開の運命と,遅めのセッションからのランダム化対照試験 (RCT) の一貫性は十分に研究されていません.
- 出版パターンを理解することは,正確な科学的解釈に不可欠です.
研究 の 目的:
- 大規模な科学会議の他のセッションと比較して,遅めのセッションで提示されたランダム化制御試験 (RCT) を比較する.
- これらのRCTの発表の運命を評価し,抽象と全長記事の間の結果の一貫性を評価する.
主な方法:
- アメリカン・カレッジ・オブ・カーディオロジーの科学会議 (1999-2002) の手作業で検索した抽象文書とウェブサイトで,RCTを特定しました.
- 電子データベースを利用して,その後の完全版の出版物を特定しました.
- 出版率,出版までの時間,および概要と論文間の有効性推定値の一貫性を比較した.
主要な成果:
- 遅刻したRCTはより大きく,設計論文が掲載される可能性が高く,出版時に品質が高くなりました.
- 遅めのセッションでのRCTは,他のセッションでのRCTよりも頻繁に,より早く出版されました.
- 抽象と公表の有効性推定値の差異は,公表されたRCTの41%で発生し,遅延および他のセッションでは同様の割合でした.
結論:
- ラテブレーキング試験は,より大きなサイズと早期公開を含む明確な特徴を示しますが,必ずしもより高い精度ではありません.
- 提示された結果と公表された結果の間の不一致は,遅刻した試験でも一般的な問題です.
- すべてのランダム化対照試験では,抽象的および完全な出版データの慎重な比較が必要である.
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