複合種酵母では,多種性の酵母における相互の遺伝子喪失と関連した複数の種種化のラウンドがある
Devin R Scannell1, Kevin P Byrne, Jonathan L Gordon
1Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland.
Nature
|March 17, 2006
まとめ
イーストの祖先における全ゲノム複製は,遺伝子の喪失につながり,種化を促した. Saccharomyces cerevisiae,S. castellii,C. glabrataにおける異なる遺伝子喪失パターンは,生殖的孤立と急速な種の出現のメカニズムを明らかにしています.
科学分野:
- 進化生物学の進化生物学について
- ゲノミクスゲノミクスとは
- イースト遺伝学 イースト遺伝学
背景:
- 共有された全ゲノム複製イベントは,Saccharomyces cerevisiae,Saccharomyces castellii,およびCandida glabrataの祖先で発生しました.
- この複製に続く後の遺伝子の喪失パターンは,この3種の酵母種間で著しく異なります.
研究 の 目的:
- 関連酵母種における全ゲノム複製後の複製遺伝子の差異的損失を調査する.
- 遺伝子の喪失が種化と生殖孤立における役割を調査する.
- 遺伝子喪失が酵母種の急速な出現を促す方法について,統一されたモデルを提案する.
主な方法:
- Saccharomyces cerevisiae,Saccharomyces castellii,Candida glabrataにおける遺伝子喪失パターンの比較ゲノム分析について.
- 差異性遺伝子喪失による非正統遺伝子の識別.
- 遺伝子の機能と,保存された複製位置での進化の速度の分析.
主要な成果:
- 遺伝子喪失の有意な差異は,3つの種間のロシウムの20%で観察されました.
- 4-7%の単一複製遺伝子は,複製された遺伝子ペアの差異的損失のために,種間のオートロゴーではありませんでした.
- 損失パターンは,生殖分離に寄与するベイトソン・ドブジャンスキー・ミュラーメカニズムを示唆する.
- 保持された複製遺伝子は,リボソーム生体生成とゆっくり進化する遺伝子のために強化されます.
結論:
- 全ゲノム複製に伴う差異性遺伝子喪失は,酵母種の発生の重要な要因である.
- パッシブな遺伝子喪失は,新しい種の出現を急速に引き起こす可能性があります.
- 観察されたパターンは,酵母における遺伝子損失によって引き起こされる種化の統一モデルを支持する.
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