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Updated: Jul 18, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
09:07

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

alphaE-cateninは,ヘッジホッグのシグナル伝達経路を調節することによって,脳皮質の大きさを制御します

Wen-Hui Lien1, Olga Klezovitch, Tania E Fernandez

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Science (New York, N.Y.)
|March 18, 2006
PubMed
まとめ

中枢神経系におけるアルファE-カタニンの消去は,ヘッジホッグ経路を活性化し,脳の過剰成長につながります. これは,アルファE-カテニンが通常,負のフィードバックループを通じて脳のサイズを調節することを示唆しています.

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