母親のうつ病と子供の精神病学的状態における寛解:STAR*D児童報告書
Myrna M Weissman1, Daniel J Pilowsky, Priya J Wickramaratne
1Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York 10032, USA. mmw3@columbia.edu
JAMA
|March 23, 2006
まとめ
母親のうつ病の治療は,子供の精神病診断と症状を効果的に軽減します. 治療されていない母性うつ病は,子供の障害率の増加と関連しており,迅速な母性精神保健医療の必要性を強調しています.
科学分野:
- 児童・青少年精神医学は,
- 母親の精神的健康について
- 臨床心理学の臨床心理学について
背景:
- 重度のうつ病の母親の子供は,早期発症,持続性,および不安,破壊性,およびうつ病の障害を悪化させる高い割合を示しています.
- これらの小児障害は,成年に至るまで続くことが多く,全般的な機能に重大な影響を及ぼします.
研究 の 目的:
- 母親のメジャーうつ病に対する効果的な薬剤治療と,母親の子供における症状と診断の軽減との関連性を調査する.
- 母親のうつ病の寛解が子供の精神病学的アウトカムに与える影響を評価する.
主な方法:
- 母親と子供のペア (7~17歳) で151人を対象とした,うつ病を和らげるための配列治療代替療法 (STAR*D) 試験のデータを活用した.
- 子どもたちは,標準化された機器 (Kiddie Schedule for Affective Disorders and Schizophrenia, Child Behavior Checklist, Child Global Assessment Scale) を使って,独立した評価者によって評価されました.
- 妊産婦のうつ病の寛解は,ハミルトン評価スケールによるうつ病スコアで3ヶ月間の薬剤治療後に≤7と定義されました.
主要な成果:
- 母親のうつ病の寛解は,子供の診断と症状の減少と有意に関連していました (11%の減少 vs 8%の増加).
- 寛解を達成した母親の子どもは,診断寛解率が33%,寛解しなかった母親の子どもは12%であった.
- 治療に対する母親の反応は,子供の結果と正の相関関係があり,子供の有意な改善には少なくとも50%の母親の反応が必要であった.
結論:
- 母親のうつ病の寛解は,母親と子供の幸福に肯定的な影響を及ぼします.
- 鬱状態のままの母親は,子供に精神疾患の発生率の増加と関連しています.
- 母親のうつ病の激しい治療は極めて重要であり,うつ病の母親の子供は,特に母親の症状が持続する場合は,慎重に評価する必要があります.
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