関連する実験動画

Updated: May 5, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
10:05

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Published on: August 13, 2012

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ABCタンパク質はクロライドチャネルに変換され,その障害がシスティック・フィブロシスを引き起こします

David C Gadsby1, Paola Vergani, László Csanády

  • 1Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, NY 10021, USA. gadsby@rockefeller.edu

Nature
|March 24, 2006
PubMed
まとめ

ABC ATPaseの一種であるCystic fibrosis transmembrane conductance regulator (CFTR) チャンネルは,アニオン流れをゲートするためにATPを使用しています. 新しい洞察は,CFTRおよび関連するタンパク質におけるATP駆動型構造変化を統合するメカニズムを明らかにしています.

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