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Updated: Jul 16, 2026

Intracellular Refolding Assay
07:18

Intracellular Refolding Assay

Published on: January 24, 2012

CHIP媒介によるストレス回復は,基板とHsp70の連続的なユビキチネーションによるものです

Shu-Bing Qian1, Holly McDonough, Frank Boellmann

  • 1Carolina Cardiovascular Biology Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

Nature
|March 24, 2006
PubMed
まとめ

Hsp70結合タンパク質 (CHIP) のカルボキシ末端は,熱ショックタンパク質70 (Hsp70) のレベルを調節する. CHIPは,ストレス中にHsp70を強化し,回復中にその分解を促進し,細胞タンパク質の折り畳み恒常性を維持します.

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