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関連する概念動画

Self-Concept01:19

Self-Concept

Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...
Understanding Self-Concept01:20

Understanding Self-Concept

The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those aschematic for...
Self Within Cultural Contexts01:30

Self Within Cultural Contexts

Cultural frameworks for understanding the self are often categorized into two broad orientations: individualism and collectivism. These paradigms influence how people define themselves, relate to others, and interpret their social worlds. Each orientation offers distinct perspectives on autonomy, responsibility, and the role of the individual within a community.Individualistic CulturesIn individualistic cultures like North America and Western Europe, identity is understood as autonomous and...
Personal Identity01:25

Personal Identity

Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness, highlighting...
Self-Presentation01:25

Self-Presentation

Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
Self-Discrepancy and Its Effects01:29

Self-Discrepancy and Its Effects

Self-discrepancy theory explains how people compare their actual self to their ideal and ought selves and how mismatches between these self-guides can lead to emotional distress. Developed by E. Tory Higgins, the theory distinguishes among three components of self-concept: the actual self, the ideal self, and the ought self. These refer respectively to how individuals perceive themselves, how they aspire to be, and how they believe they are obligated to be. Emotional well-being, self-esteem,...

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関連する実験動画

Updated: Jul 20, 2026

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation
06:53

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation

Published on: March 1, 2017

自己の複雑さについて

Rudensky AYu1, S Rath, P Preston-Hurlburt

  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Nature
|October 27, 1991
PubMed
まとめ

新しい抗体,Y-Aeは,MHCクラスII分子に結合する特定の自己ペプチドを特定します. この発見は,T細胞選択中に提示される自己ペプチドの種類が限られていることを示唆しています.

科学分野:

  • 免疫学 免疫学とは
  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学

背景:

  • 自己メジャーヒストコンパティビリティ・コンプレックス (MHC) 分子が提示する自己ペプチドは,胸腺内のT細胞発育において重要な役割を果たします.
  • T細胞のポジティブとネガティブの両方の選択は,これらの自己ペプチド-MHC相互作用によって影響を受けます.
  • 自己ペプチドの性質とプレゼンテーションを理解することは,免疫システムの調節を解読する鍵です.

研究 の 目的:

  • MHCクラスIIの分子によって提示される特定の自己ペプチドを特定し,特徴づけること.
  • この自己ペプチドがT細胞の選択過程における役割を調査する.
  • 抗原を提示する細胞にMHCクラスII分子によって提示される自己ペプチドの複雑性を決定する.

主な方法:

  • 新型MHCIIクラス限定モノクローナル抗体のY-Ae.の開発と応用
  • Y-Ae.を使用したMHCクラスIIの自己ペプチドの検出と定量化.
  • Y-Aeが抗原を呈現する細胞と胸膜の上皮細胞に結合する分析.

主要な成果:

  • Y-Ae抗体は,MHCクラスII分子に結合する主要な自己ペプチドを特定します.

さらに関連する動画

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A Modified Mirror Test as a Visual Guide for the Self-awareness Trait in Wild Antarctica Penguins, Pygoscelis adeliae
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関連する実験動画

Last Updated: Jul 20, 2026

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation
06:53

Creating Virtual-hand and Virtual-face Illusions to Investigate Self-representation

Published on: March 1, 2017

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
12:55

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

A Modified Mirror Test as a Visual Guide for the Self-awareness Trait in Wild Antarctica Penguins, Pygoscelis adeliae
04:51

A Modified Mirror Test as a Visual Guide for the Self-awareness Trait in Wild Antarctica Penguins, Pygoscelis adeliae

Published on: July 8, 2025

  • Y-Aeは,自己抗原を呈現する細胞上の関連するMHCクラスII分子の約12%と結合する.
  • 検出された自己ペプチドは,MHC分子から溶解されたいくつかの主要なペプチドの1つであり,複雑性が限られていることを示しています.
  • Y-Aeは,ネガティブな選択に関与する抗原を呈現する細胞を染色するが,ポジティブな選択に関与する胸膜皮質の上皮細胞は染色しない.
  • 結論:

    • CD4T細胞にシグナルを送るのに十分なレベルで自己MHCクラスII分子によって提示される自己ペプチドは,複雑性が限られている.
    • セルフペプチド:セルフMHCクラスII複合体の微分発現は,腸内T細胞選択において重要な役割を果たす可能性があります.
    • Y-Ae抗体は,自己ペプチド表現とT細胞の選択を研究するための貴重なツールです.