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Updated: Jun 23, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Published on: April 13, 2015

INK4/ARF局所を抑制することにより,Cdc6の腫瘍性活性が発揮される

Susana Gonzalez1, Peter Klatt, Sonia Delgado

  • 1Tumor Suppression Group, Spanish National Cancer Research Center (CNIO), E-28029 Madrid, Spain.

Nature
|March 31, 2006
PubMed
まとめ

過剰発現したCdc6は,ヘテロクロマチンを形成することによってINK4/ARF腫瘍抑制器の位置を抑制し,がんの発症を促進します. このメカニズムは,RD ((INK4/ARF) 制御要素を巻き込み,Cdc6を細胞の不死化と変異と結びつける.

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