地域社会での急性感染後に深静脈栓塞や肺栓塞のリスク
Liam Smeeth1, Claire Cook1, Sara Thomas2
1Departments of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Lancet (London, England)
|April 4, 2006
まとめ
急性感染症,特に尿路感染症は,深静脈血栓症 (DVT) と肺栓塞症 (PE) を含む静脈血栓塞栓症 (VTE) のリスクを一時的に増加させます. 感染後の最初の数週間でリスクが最も高く,1年後にベースラインに戻ります.
科学分野:
- エピデミオロジー エピデミオロジー
- 血管医学 血管医学とは
- 感染症 感染症とは
背景:
- 急性感染症は,動脈性心血管疾患のリスクを高めることが知られています.
- 静脈性血栓塞栓性疾患のリスクに対する急性感染症の影響は,あまり理解されていない.
- この研究では,急性感染症後の静脈血栓塞栓症の一時的なリスクを調査しています.
研究 の 目的:
- 急性感染症が一時的に静脈血栓塞栓症 (VTE) のリスクを高めるかどうかを判断する.
- 呼吸道および尿路感染症後の深静脈血栓症 (DVT) と肺栓塞 (PE) のリスクを定量化するために.
主な方法:
- セルフ・コントロール・ケース・シリーズ・メソッドを用いた.
- イギリスの健康改善ネットワーク (THIN) データベース (1987-2004) から得られたデータ.
- 分析には,最初のDVT (n=7278) と最初のPE (n=3755) 症例が含まれました.
主要な成果:
- 尿路感染症は,DVTとPEのリスクを大幅に増加させ,2週間以内にピークに達しました.
- DVTとPEの発生率は,それぞれ約2.10と2.11でした.
- リスクは数ヶ月で減少し,1年後にベースラインに戻った;呼吸器感染症はまた,DVTのリスクを高めました.
結論:
- 急性感染症は,コミュニティにおける静脈性血栓塞栓性イベントの一時的なリスクの増加と関連しています.
- 感染は静脈性血栓塞栓症の原因として認識されるべきである.
- 発見は,急性感染症とVTEの間の潜在的な因果関係を示唆しています.
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