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Updated: Jul 18, 2026

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

受容器最適化の概念:RGDペプチドをターゲットにすること

Wei Chen1, Chia-en Chang, Michael K Gilson

  • 1Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA.

Journal of the American Chemical Society
|April 6, 2006
PubMed
まとめ

高結合親和度を持つ合成受容体を設計することは,非常に難しいことです. この研究は,溶解とエントロピーのような相反する力が受容体の効率を制限することを明らかにしているが,低分子量受容体ではタンパク質のような親和性が達成可能である.

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The Two-State Receptor Model

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