成長因子とがんについて
1Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
Science (New York, N.Y.)
|November 22, 1991
まとめ
癌は正常な成長因子信号伝達経路をハイジャックする. 癌細胞の腫瘍遺伝子は成長因子を模倣し,細胞の増殖を促し,細胞の変異現象と遺伝的イベントを通じて悪性腫瘍に潜在的に影響を与える.
科学分野:
- 分子腫瘍学 分子腫瘍学
- 細胞シグナル伝達 細胞信号伝達
- 癌生物学 癌生物学について
背景:
- 成長と分化を含む正常な細胞機能は,成長因子を含む複雑なシグナル伝達経路によって調節されます.
- これらの重要な経路は,がんの発生と進行において,しばしば破壊または破壊される.
研究 の 目的:
- 成長因子のシグナル伝達経路が癌でどのように変化するか解明する.
- 腫瘍遺伝子が正常な細胞サイクル進行と分化を妨害する役割を理解する.
- 異常な成長因子シグナリングが癌の発達と治療戦略に与える影響を調査する.
主な方法:
- ミトゲンシグナル伝達に関与する腫瘍遺伝子の識別と特徴付け.
- 成長因子シグナル伝達との関係における細胞サイクル進行の分析.
- 構成的成長経路の活性化による癌細胞におけるフェノタイプの調節の調査.
- 癌の遺伝的イベントの文脈におけるパラクリン信号の検討.
主要な成果:
- 腫瘍遺伝子は,ミトゲンシグナル伝達経路の重要な点での機能を特定した.
- 癌細胞は腫瘍遺伝子を利用して,細胞サイクル進行に必要な特定の成長因子の機能を代用します.
- 癌細胞における異常な成長因子シグナリングは,細胞のフェノタイプを変化させ,悪性腫瘍に寄与する.
結論:
- 腫瘍遺伝子による正常な成長因子信号伝達経路の破壊は,がんの特徴である.
- これらの変化した経路を理解することは,標的を絞ったがん治療法の開発に不可欠です.
- これらの異常なシグナリングカスケード内の重要なステップを特にターゲットとする新しい治療戦略が浮上しています.
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