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Updated: Jul 18, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

ダーウィンの進化論は,タンパク質に適合する変異の経路をごくわずかしかたどることができない

Daniel M Weinreich1, Nigel F Delaney, Mark A Depristo

  • 1Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. dmw@post.harvard.edu

Science (New York, N.Y.)
|April 8, 2006
PubMed
まとめ

バクテリアの抗生物質耐性の高い進化の経路は,非常に制限されています. ほとんどの突然変異の組み合わせは,プレオトロピーによりアクセスできないため,タンパク質の進化は予測可能になります.

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Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

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Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence11:51

Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence

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