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Updated: Jun 7, 2026

Analysis of Histone Antibody Specificity with Peptide Microarrays
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JmjCを含むH3K9デメチラーゼであるJHDM2Aは,アンドロゲン受容体による転写活性化を促進する

Kenichi Yamane1, Charalambos Toumazou, Yu-ichi Tsukada

  • 1Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Cell
|April 11, 2006
PubMed
まとめ

研究者らは,ヒストンH3ライシン9 (H3K9) からメチル群を除去する新しいヒストン脱メチラーゼであるJHDM2Aを特定した. この酵素は,H3K9メチル化を逆転させることで,ホルモン依存性遺伝子の活性化に不可欠です.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers10:28

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