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Updated: Jul 6, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
19:58

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

温和な条件下で亜鉛アミドエノラートによるパラジアム触媒による分子間アルファアリレーション

Takuo Hama1, Darcy A Culkin, John F Hartwig

  • 1Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|April 13, 2006
PubMed
まとめ

この研究では,亜鉛エノラートを使用した,パラジウム触媒によるアルファアリレーションとアミドのビニレーションを導入しています. この方法は,機能化されたアミドを合成するための汎用的なアプローチを提供し,有機化学における合成の可能性を拡大します.

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Acidity of 1-Alkynes02:42

Acidity of 1-Alkynes


The acidic strength of hydrocarbons follows the order: Alkynes > Alkenes > Alkanes. The strength of an acid is commonly expressed in units of pKa — the lower the pKa, the stronger the acid. Among the hydrocarbons, terminal alkynes have lower pKa values and are, therefore, more acidic. For example, the pKa values for ethane, ethene, and acetylene are 51, 44, and 25, respectively, as shown here.
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Acid-Catalyzed α-Halogenation of Aldehydes and Ketones

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In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
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Acid-Catalyzed Aldol Addition Reaction

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