Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment.

Molecular biology of the cell·2026
Same author

The Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage.

International journal of molecular sciences·2025
Same author

Different relative scalings between transient forces and thermal fluctuations tune regimes of dynamic clustering.

Physical review. E·2025
Same author

The centromere bottlebrush requires a multi-microtubule attachment.

Molecular biology of the cell·2025
Same author

Centromeres are stress-induced fragile sites.

Current biology : CB·2025
Same author

Closing the loops: chromatin loop dynamics after DNA damage.

Nucleus (Austin, Tex.)·2024

関連する実験動画

Updated: May 12, 2026

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 13, 2014

NoCut: チェック中のサイトキネシス

Kerry Bloom1

  • 1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. kbloom@email.unc.edu

Cell
|April 18, 2006
PubMed
まとめ

NoCutと呼ばれる新しい経路は,染色体分離を芽生えた酵母における細胞分裂と結びつける. この経路は,オーロラキナーゼを使用して,細胞極性タンパク質Boi1およびBoi2.2を介して細胞運動を制御します.

科学分野:

  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • 細胞分裂のプロセスであるサイトキネシスは,染色体分離の完了と正確に調整されなければならない.
  • この調整の調節は,ゲノムの安定性を維持するために極めて重要です.

研究 の 目的:

  • 染色体分離を芽生える酵母における細胞運動と結びつける新しい経路を特定し,特徴づけること.
  • ミトーシスから細胞分裂への移行を制御する分子機構を解明する.

主な方法:

  • モデル生物として芽生える酵母 (Saccharomyces cerevisiae) を利用した.
  • タンパク質の機能と経路の相互作用を調査するために,遺伝的および細胞生物学的な技術を使用しました.

主要な成果:

  • 染色体分離と細胞運動を結びつけるNoCutと呼ばれる新しい経路について説明しました.
  • スピンドルミッドゾーンでNoCut経路内の重要なレギュレータとしてオーロラキナーゼ (Ipl1) を特定しました.
  • Ipl1が細胞極性タンパク質Boi1およびBoi2.2との相互作用により,細胞運動を否定的に調節することを実証した.

結論:

さらに関連する動画

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

関連する実験動画

Last Updated: May 12, 2026

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
09:52

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

Published on: March 13, 2014

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

  • NoCut経路は,細胞運動が始まる前に染色体分離が完了することを保証する重要なリンクを提供します.
  • オーロラキナーゼと細胞極性タンパク質Boi1/Boi2は,適切な染色体分離が起こるまで,細胞運動を否定的に調節する重要な役割を果たします.