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Updated: Jan 14, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

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人間の胚性幹細胞におけるPolycombによる発達調節体の制御

Tong Ihn Lee1, Richard G Jenner, Laurie A Boyer

  • 1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

Cell
|April 25, 2006
PubMed
まとめ

ポリコンブ抑制複合体2 (PRC2) は,ヒト胚性幹細胞の重要な発達遺伝子を結合し,それらを抑制して多能性を維持します. これらの遺伝子は,分化時に活性化され,PRC2を突出します.

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In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity07:52

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Here we describe a rapid and direct in vivo CRISPR/Cas9 screening methodology using ultrasound-guided in utero embryonic lentiviral injections to simultaneously assess functions of several genes in the skin and oral cavity of immunocompetent...
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