葉酸:公衆衛生上の課題
Monika Eichholzer1, Otmar Tönz, Roland Zimmermann
1Institute of Social and Preventive Medicine, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. eichholz@ifspm.unizh.ch
Lancet (London, England)
|April 25, 2006
まとめ
多くの女性は葉酸サプリメントを摂取しないため,神経管の不全が持続する. いくつかの国の強制的な要塞化は欠陥を大幅に軽減したが,より広範な戦略が必要である.
科学分野:
- 公衆衛生は公衆衛生である.
- 栄養科学とは,栄養科学である.
- 予防医学は,予防的な医療です.
背景:
- 公衆衛生キャンペーンは,神経管欠陥 (NTD) を予防するために葉酸のサプリメントを推奨しています.
- 多くの女性はこれらの勧告を遵守しないため,NTDは依然として懸念事項です.
- 遵守率の低さは,教育水準,年齢,計画外妊娠などと関連している.
研究 の 目的:
- NTD率に対する葉酸の補給と強化の有効性を評価する.
- 課題を特定し,葉酸の状態の改善のための代替公衆衛生戦略を提案する.
主な方法:
- 世界的に実施されている公衆衛生キャンペーンと強化政策の見直し.
- 強制的な強化と強制的な強化のない国におけるNTD率の分析.
- 集団の葉酸とホモシステインの状態の評価.
主要な成果:
- 米国,カナダ,チリでの強制的な葉酸強化は,NTD (31-78%) を大幅に減少させた.
- 多くのヨーロッパ諸国では,NTDの減少は見られず,勧告への遵守が低いことを示している.
- 強化されていない国々の一般人口は,しばしば,不十分な毎日の食物葉酸の摂取量を持っています.
結論:
- 強制的な葉酸強化は,NTDの減少と人口の葉酸の状態の改善に効果的です.
- 強制的な強化に対する課題には,証明されていない利点と,健康上のリスクと選択に関する懸念が含まれています.
- 葉酸の状態を改善し,世界的にNTDを予防するために,創造的な公衆衛生アプローチが必要である.
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