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マクロファージ・メタルエラスタゼは,トランスジェニックウサギの動脈硬化症の進行を加速する

Jingyan Liang¹, Enqi Liu, Ying Yu

¹Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.

|April 26, 2006

まとめ

マクロファージ・メタロエラスタゼ (MMP-12) の過剰発現は,ウサギの動脈硬化症の発症を加速する. これは,MMP-12が,この心血管疾患の進行を促進する上で重要な役割を果たしていることを示唆しています.

科学分野:

心血管研究循環器科の研究
生物医学科学生物医学科学とは
病理学パトロジー

背景:

マクロファージ・メタルエラスタゼ (マトリックス・メタルプロテインアゼ[MMP]-12) は,動脈硬化性病変において上昇している.
動脈硬化症の発症と進行におけるMMP-12の役割は不明である.

研究の目的:

動脈硬化症におけるMMP-12の病理学的役割を調査する.
MMP-12トランスジェニック (Tg) のウサギとTg以外のウサギの動脈硬化症の発症を比較する.

主な方法:

MMP-12 TgとTgでないウサギは,高コレステロール血症を誘発するために,コレステロール豊富な食事を与えられました.
動脈硬化症の進行は,さまざまな期間と高コレステロール血症のレベルで評価されました.
ヒスト学的分析では,病変の大きさ,質,マクロファージの浸透,および弾性ラミナの整合性を調べました.

主要な成果:

低レベルの高コレステロール血症では,動脈硬化症の有意な違いは観察されなかった.
より高い高コレステロール血量で,より長い期間,Tgウサギは,大動脈と冠動脈でより広範な動脈硬化を示しました.
Tgウサギの病変では,マクロファージの浸透が増加し,弾性ラミナが破壊され,動脈瘤のような形成が示されました.

結論:

MMP-12の過剰発現は,ウサギの動脈硬化を促進する.
マクロファージ由来のMMP-12は,動脈硬化症の進行に関与しています.

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