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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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変形成長因子-βは,T(H) 17系統の発展を誘導する

Paul R Mangan1, Laurie E Harrington, Darrell B O'Quinn

  • 1Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-2170, USA.

Nature
|May 2, 2006
PubMed
まとめ

変換成長因子β (TGF-β) は,IL-23Rを上調することで,T-ヘルパー-17 (T(H) 17) 細胞の発達に不可欠です. このサイトカインシグナル伝達経路は,細胞外細菌に対する適応免疫の鍵であり,自己免疫疾患に関与しています.

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