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Updated: May 12, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

アルコール依存症に対する薬物療法と行動介入の組み合わせ:COMBINE研究:ランダム化制御試験

Raymond F Anton1, Stephanie S O'Malley, Domenic A Ciraulo

  • 1Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA. antonr@musc.edu

JAMA
|May 4, 2006
PubMed
まとめ

ナルトレクソンが医療管理またはCBI (Combined Behavioral Interventions) と併用された場合,アルコール禁断率が改善されました. アカムプロサートは有意な効果を示さなかったし,ナルトレクソンまたはCBI単独を上回る組み合わせは存在しなかった.

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Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods09:29

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Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Combined Effects of Drugs: Antagonism

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Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
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Drug Therapy

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