ポリグルタミン酸コア・シェルの微球の形成と特徴
Elizabeth M Dibbern1, Farah Jean-Jacques Toublan, Kenneth S Suslick
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
Journal of the American Chemical Society
|May 18, 2006
まとめ
研究者らは,標的型薬物投与のための新しいポリグルタマート微球を開発しました. これらの小さく,安定した膀は,医学における生物互換性および生物分解性材料のアプリケーションを改善する可能性を秘めています.
科学分野:
- バイオマテリアル科学 バイオマテリアル科学
- ナノテクノロジー ナノテクノロジー
- 薬物の配送システムです.
背景:
- 生物適合性および生物分解性のある膀は,薬物およびイメージング剤の臓器標的投与に不可欠です.
- 以前の研究では,タンパク質のクロスリンクによって安定した,水害性の物質を運ぶために,水害性の内部を持つタンパク質の微球を実証した.
研究 の 目的:
- ポリグルタマートを使用した新しいコア・シェル・マイクロスフィアの開発と特徴付けを,潜在的 vivo 応用のために行う.
- これらの新しいポリグルタマート微球の安定性と形成機構を調査する.
主な方法:
- コア・シェルのマイクロスフィアは,ポリグルタマートを使用して,超音波によるわずかに基本的なpH条件下で合成されました.
- 生理学的条件下での粒子の大きさと安定性を評価した.
主要な成果:
- ポリグルタマート微球は,以前のタンパク質ベースの微球と比較して,より小さなサイズで成功裏に形成されました.
- これらの微球は,体内での使用に適した条件下で安定性を示した.
- マイクロスフィアの安定性は,コバルントクロスリンクではなく,水素結合ネットワークに起因した.
結論:
- ポリグルタマート微球は,薬剤およびイメージング剤の投与のための生物適合性および生物分解性ベジクルの有望な新しいクラスを表しています.
- 観察された安定性とより小さなサイズは,それらをin vivoアプリケーションに適した候補者にします.
- 水素結合に依存する形成メカニズムは,膀の安定化のための共振クロスリンクの代替案を提供します.
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