胸の痛風のリスクと,ビタミンA,C,E,カロチンの血濃度,およびカロチンのリスク
R A Riemersma1, D A Wood, C C Macintyre
1Department of Cardiology, University of Edinburgh.
Lancet (London, England)
|January 5, 1991
まとめ
この研究では,より高いビタミンEレベルは,アンギナ発症のリスクの低下と関連していることが判明しました. 抗酸化物質に富んだ食事,特にビタミンEが豊富である食事は,心臓の健康に有益である可能性があります.
科学分野:
- 栄養学的流行病学について
- 心血管疾患に関する研究
- 抗酸化物質の研究
背景:
- 胸痛は冠動脈疾患の重要な表れである.
- 抗酸化物質を含む食生活要因は,心血管の健康における役割について調査されています.
- これまでの研究は,ビタミンと心臓病のリスクとの潜在的な関連を示唆しています.
研究 の 目的:
- ビタミンA,C,E,カロチン等の血濃度と胸痛のリスクとの関連性を調べる.
- 喫煙などの混同要因がこれらの関連に及ぼす影響を調査する.
- 特定の抗酸化物質を特定し,アンギナから身を守る.
主な方法:
- 110人のアンギナ患者と394人の対照群 (35~54歳の男性) を対象とした集団ベースの症例対照研究.
- 症例識別のための胸痛アンケートを使用して,ビタミンA,C,E,カロチンの血濃度の評価.
- 年齢,喫煙,血圧,脂質,相対体重などの混同変数を調整するための統計分析.
主要な成果:
- ビタミンC,E,カロチンの血濃度は,アングイナリスクと有意な逆関係を示した.
- ビタミンAは,アンギナリスクと有意な関連性を示さなかった.
- ビタミンEは,複数の混同要因を調整した後も,アンギナリスクと独立して逆に関連しており,最も低い対最も高いクインチルのオッズ比は2.68でした.
結論:
- ビタミンEの血濃度の上昇は,アンギナ・ペクトリスのリスクの低下と独立して関連しています.
- 天然の抗酸化物質,特にビタミンEの食事摂取は,冠動脈疾患のリスクが高い人群にとって有益である可能性があります.
- 心血管疾患の予防における特定の抗酸化物質の役割に関するさらなる研究が必要である.
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