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Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker
Published on: December 18, 2014
ベンゾジアゼピン耐性をフルマゼニルで逆転させる可能性
I Savic1, L Widén, S Stone-Elander
1Department of Clinical Neurophysiology, Karolinska Hospital, Stockholm, Sweden.
Lancet (London, England)
|January 19, 1991
まとめ
ベンゾジアゼピン抗剤であるフルマゼニルは,離脱発作を引き起こすことなく,患者におけるベンゾジアゼピンに対する耐性を逆転させることがあります. 断続的な治療の可能性については,さらなる研究が推奨されます.
科学分野:
- 神経科学は神経科学である.
- 薬理学 薬理学とは
- エピレプトロジーはエピレプト学です.
背景:
- ベンゾジアゼピンは通常,の治療に使用されますが,耐性につながる可能性があります.
- フルマゼニルなどのベンゾジアゼピン抗剤は,この耐性を管理する方法を提示する可能性があります.
研究 の 目的:
- フルマゼニルが,離脱発作を誘発することなく,ベンゾジアゼピン耐性を逆転させることができるかどうかを調査する.
- フルマゼニルの抗作用と受容体の占有率を評価するために.
- 許容性を逆転させるための最適な投与量を決定するために.
主な方法:
- 部分発作と一般発作の12人の患者による脳波 (EEG) 研究.
- 静脈注射フルマゼニル (1,5 mgおよび15 mg) の投与量によって異なる受容体占有率に関する研究.
- クロナゼパムに耐える患者3人に1.5mgのフルマゼニル投与.
主要な成果:
- フルマゼニルは,部分発作における性放出に対して,短期的な,投与量に依存しない抑制効果を示した.
- フルマゼニルの1.5mgは受容体の55%を占め,15mgはほぼすべての受容体を占める.
- クロナゼパムに耐えた3人の患者は,1.5mgのフルマゼニル投与後6~21日間,発作がなくなりました.
結論:
- フルマゼニルは,てんかんにおけるベンゾジアゼピン耐性を逆転させる可能性を示しています.
- ベンゾジアゼピン抗体による中断的な治療は,ベンゾジアゼピン耐性の管理のためのさらなる調査を正当化します.
- フルマゼニルは,ベンゾジアゼピン耐性を経験している患者のための治療戦略を提供することができます.
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