筋肉繊維の種類と,いつものくしゃみ
S Smirne1, S Iannaccone, L Ferini-Strambi
1Sleep Disorders Centre, State University and Scientific Institute, Milan, Italy.
Lancet (London, England)
|March 9, 1991
まとめ
阻害性睡眠時無呼吸症 (OSA) の初期の兆候である習慣的なくしゃみは,上部呼吸道における異常な筋肉繊維タイプと関連しています. 具体的には,いつものくしゃみをする人は,中間の縮筋 (MPCM) 構造の変化を示し,OSAにおける筋肉調節不調の役割を示唆しています.
科学分野:
- 生理学 生理学とは
- スリープ・メディシン (睡眠医学)
- 筋肉生物学 筋肉生物学
背景:
- 阻害性睡眠時無呼吸症 (OSA) は,上部呼吸器の解剖学的異常と関連しています.
- 筋肉調節障害は,OSAの病原性にも関わっています.
- 習慣的なくしゃみは,OSAの初期段階と考えられています.
研究 の 目的:
- 普段のくしゃみをする人と,そうでない人との比較で,中縮筋 (MPCM) の構造的特徴を調査する.
- 習慣的なくしゃみやOSAに寄与する潜在的な筋肉ベースのメカニズムを探求する.
主な方法:
- 13人の成人の男性からのMPCM繊維タイプ (I,IIa,IIb) の組織学的な分析 (4人の習慣的なスノーカー,9人の非スノーカー).
- MPCM繊維分布とスノーカーと非スノーカーの間の直径の比較.
- ミオパシーまたは神経原性変化の評価.
主要な成果:
- ノン・スノーカーにおけるMPCMは,典型的な四肢筋よりも小さな繊維直径を示し,タイプIとIIaの繊維の割合が高く,タイプIIbの繊維が少ない.
- 習慣的にくしゃみをする人は,非くしゃみをする人と比較して,MPCM繊維分布 (低タイプIとIIb,高タイプIIa) が著しく異常を示した (p <0.001).
- 習慣的なくしゃみをする人のタイプIIa繊維は,筋痛性または神経原性疾患の証拠のない高縮性であった.
結論:
- 習慣的なくしゃみは,上部呼吸道筋 (MPCM) 繊維の種類分布と縮の特定の変化と関連しています.
- これらの発見は,筋肉調節不調と,習慣的なくしゃみとOSAの発達におけるモーターニューロン活動における適応的変化の潜在的な役割を示唆しています.
- モーターニューロン機能と MPCM 適応を結びつける正確なメカニズムを明らかにするために,さらなる研究が必要である.
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