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Updated: Jul 30, 2026

06:55
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
妊娠56日~66日のコリアン・ヴィルス採取後の重度の肢体異常
H V Firth1, P A Boyd, P Chamberlain
1Department of Medical Genetics, Churchill Hospital, Oxford, UK.
Lancet (London, England)
|March 30, 1991
まとめ
妊娠初期におけるコリアンビルス採取 (CVS) は,新生児の重度の肢体異常と関連している可能性があります. CVSがこれらの発達障害の原因であるかどうかを確認するためにさらなる研究が必要です.
科学分野:
- 医学遺伝学 医学遺伝学
- 産前診断 産前診断
- 発達生物学 発達生物学とは
背景:
- コリアンビルスサンプリング (CVS) は,一般的な産前診断手順です.
- 早期発症した四肢の異常は,深刻な先天性疾患である.
研究 の 目的:
- コリアンビルス採取 (CVS) と重度の肢体異常との潜在的な関連性を調査する.
- CVS後の口四肢低生性症候群および横断四肢縮小障害の発生率を評価する.
主な方法:
- 妊娠56~66日の間にCVSを受けた289人の妊娠を遡及的に分析した.
- 子孫における重度の四肢異常の識別と分類.
主要な成果:
- CVSで診断された289人の妊娠のうち,5例の重度の四肢異常が特定されました.
- 4人の乳児は,口四肢ヒポゲネシス症候群を発症した.
- 1人の乳児は,末期的な横断四肢縮小欠陥を患っていました.
結論:
- 予期以上に重度の四肢異常の発生率は,CVS後に観察されました.
- これらの発見は,これらの発達異常におけるCVSの潜在的なエチオロギー的な役割を示唆しています.
- CVSと手足の異常形成の間の因果関係を確認するために,さらなる調査が必要である.
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