エイズ関連非ホジキンリンパ腫
V Beral1, T Peterman, R Berkelman
1ICRF Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK.
Lancet (London, England)
|April 6, 1991
まとめ
既得免疫不全症候群 (AIDS) に関連するノン・ホジキンリンパ腫は,HIV感染者において著しく多く見られる. エプスタイン・バーウイルスのような感染症が関与するかもしれないが,エイズ患者のリンパ腫の全種類を説明する単一の原因は存在しない.
科学分野:
- エピデミオロジー エピデミオロジー
- 腫瘍学 腫瘍学
- 感染症 感染症は感染症です.
背景:
- ノン・ホッジキンリンパ腫 (NHL) は,ヒト免疫不全ウイルス (HIV) 感染症の既知の合併症です.
- AIDSに関連するNHLの特定の疫学と病因を理解することは,患者のケアと研究にとって不可欠です.
研究 の 目的:
- エイズ関連のノンホジキンリンパ腫の流行病学と病因を調査する.
- エイズ患者の異なるリンパ腫サブタイプの発生率と特徴を分析する.
主な方法:
- 1989年6月30日までの97,258件の報告されたエイズ症例のデータを分析し,疾病管理センター (CDC) によって収集しました.
- 免疫芽細胞リンパ腫,脳の原発リンパ腫,バーキットリンパ腫を含むNHLサブタイプの分類.
- リンパ腫発症に関連する人口統計的要因 (年齢,人種,性別) とリスク要因 (血友病,地理的起源,HIV感染方式) の検討.
主要な成果:
- エイズ患者の2.9% (97,258例のうち2824例) がノンホッジキンリンパ腫であり,一般人よりも約60倍多い.
- 免疫原性リンパ腫の罹患率は年齢とともに増加し,原発性脳リンパ腫は各年齢層にわたって一貫したままでした.
- バーキットのリンパ腫の頻度は,青少年と若年成人 (10〜19歳) でピークに達し,免疫抑制では通常見られないパターンです.
- リンパ腫は黒人よりも白人,女性よりも男性に多く見られた.
- 高頻度は,血友病や凝固障害の患者で,低頻度は,ヘテロセクシュアル HIV 感染のカリブ海やアフリカの患者で観察されました.
結論:
- エピデミオロギーのデータによると,エプスタイン・バーウイルスなどの感染症剤は,エイズに関連するNHL発症に関与している可能性があるが,単一の病原体がある可能性は低い.
- ブルキットのリンパ腫とHIV感染の強い関連性は,他の免疫抑制性疾患における希少性にもかかわらず,依然として重要で不思議な観察である.
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