トリアゾラームの使用による翌日の記憶障害
E O Bixler1, A Kales, R L Manfredi
1Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey 17033.
Lancet (London, England)
|April 6, 1991
まとめ
鎮静催眠薬であるトリアゾラムは,使用者の間で,翌日の記憶障害と記憶喪失をしばしば引き起こした. テマゼパムとプラセボは,これらの重要な記憶障害を示さなかったので,トリアゾラームが示された.
科学分野:
- 薬理学 薬理学とは
- 神経科学は神経科学である.
- 認知心理学とは,認知心理学である.
背景:
- ベンゾジアゼピンは通常,不眠症に処方されます.
- 短期間のベンゾジアゼピンの認知的副作用を理解することは,患者の安全にとって非常に重要です.
- トリアゾラムとテマゼパムは,短期間作用するベンゾジアゼピンで,薬理学プロファイルが異なります.
研究 の 目的:
- トリアゾラム,テマゼパム,プラセボの寝前の投与後の翌日の記憶障害の有病率,発生率,程度を評価する.
- トライアゾラムの記憶を損なう効果をテマゼパムとプラセボと比較するために.
- 薬物使用と記憶障害の発生との関係を調査する.
主な方法:
- ダブルブラインド,並列グループ研究デザインが採用されました.
- 参加者は,トリアゾラム,テマゼパム,またはプラセボを寝前の用量として受けました.
- 活動の翌日の記憶と即時/遅延リコールが評価されました.
主要な成果:
- トリアゾラーム群の6人中5人が,翌日の記憶障害/記憶喪失 (40%率) を報告した.
- テマゼパムまたはプラセボ群では記憶障害のエピソードが報告されていません.
- テマゼパムまたはプラセボと比較して,トリアゾラムで遅延記憶の障害は著しく増加しました.
結論:
- トリアゾラムは,翌日の記憶障害/記憶喪失の高い発生率と関連しています.
- トリアゾラムによる認知障害は,有機的な脳の機能障害のスペクトルを表す可能性があります.
- この研究では,テマゼパムは次の日の記憶障害を有意に示さなかった.
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