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Updated: Jul 21, 2026

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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
ベッカーの筋ジストロフィーの流行と発生率
K M Bushby1, M Thambyayah, D Gardner-Medwin
1Department of Neurobiology and Genetics, University of Newcastle upon Tyne, UK.
Lancet (London, England)
|April 27, 1991
まとめ
ベッカーの筋縮症 (BMD) は,これまで考えられていたよりも一般的であり,イングランドでは2.38/100,000の罹患率があります. その出生発生率は,ドゥシェンヌ筋縮症 (DMD) の約3分の1です.
科学分野:
- 神経学 神経学とは
- 遺伝学 遺伝学とは
- エピデミオロジー エピデミオロジー
背景:
- ベッカーの筋縮症 (BMD) は,まれな遺伝的な神経筋疾患である.
- BMDの有病率と発生率に関する以前の推定値は,その発生を完全に反映していない可能性があります.
研究 の 目的:
- イギリス北部の保健地域におけるベッカーの筋縮症 (BMD) の有病率と発生率を決定する.
- BMDの疫学をダッチェンヌ筋縮症 (DMD) と比較する.
主な方法:
- 地域の神経学および実験室記録による患者識別,および医師のアウトリーチ.
- cDNAプローブおよび/または筋肉生検サンプルのディストロフィン免疫マーキングを用いた診断確認.
- BMDとDMDの流行病学的データの比較.
主要な成果:
- この地域では,生きた73人のBMD患者を特定し,人口10万人に2.38の罹患率を示した.
- BMDの罹患率は,ダッチェンヌ筋縮症 (DMD) と比べて10万人に2.48である.
- BMDの累積出産率 (男性出産の1万8,450人に1人) は,DMDのおよそ3分の1 (男性出産の5,618人に1人) である.
結論:
- ベッカーの筋縮症 (BMD) は,以前に推定されたよりより一般的であるように見える.
- この調査結果は,BMDの公衆衛生への影響が著しく過小評価されていることを示唆している.
- これらの発見をより広範な集団で確認するために,さらなる疫学研究が必要である.
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