関連する実験動画
Updated: Jan 10, 2026
01:24
Nephrotic Syndrome I : Introduction
Published on: June 19, 2025
476
CD8は,細胞毒性T細胞の発達には必要ですが,ヘルパーT細胞には必要ありません
W P Fung-Leung1, M W Schilham, A Rahemtulla
1Ontario Cancer Institute, University of Toronto, Canada.
Cell
|May 3, 1991
まとめ
CD8発現が欠けているマウスは,細胞毒性Tリンパ球の反応が著しく低下することを示しています. これは,CD8が細胞毒性T細胞の発達に不可欠であるが,ヘルパーT細胞の機能には欠かせないことを示している.
科学分野:
- 免疫学 免疫学とは
- T細胞生物学について
- 分子遺伝学 分子遺伝学
背景:
- CD8は細胞表面のグリコタンパク質で,細胞毒性Tリンパ球に存在します.
- T細胞の発達と機能におけるその役割は極めて重要です.
- CD8の機能を理解するには,その欠如を研究する必要があります.
研究 の 目的:
- Tリンパ球の発達と機能におけるCD8の役割を調査する.
- CD8が細胞毒性Tリンパ球の成熟と選択に不可欠かどうかを判断する.
- CD8欠乏がヘルパーT細胞の発達に与える影響を評価する.
主な方法:
- Lyt-2遺伝子の破壊によるCD8発現が欠けている変異性マウス株の生成.
- 周辺リンパ性臓器におけるTリンパ球集団の分析.
- アロアンチゲンとウイルス抗原に対する細胞毒性Tリンパ球の反応の評価.
- Tリンパ球の増殖反応とB細胞の助けを評価する.
主要な成果:
- CD8発現が欠けているマウスは,周辺リンパ性臓器にCD8+Tリンパ球が欠けている.
- アロアンチゲンとウイルス抗原に対する細胞毒性Tリンパ球の反応が著しく低下します.
- CD4+Tリンパ球の集団とその機能 (増殖,B細胞の助け) は変わらない.
- CD8は,クラスIのMHC制限型細胞毒性Tリンパ球の成熟と陽性選択に必要である.
結論:
- CD8は,機能的な細胞毒性Tリンパ球の発達に不可欠です.
- クラスIIのMHC限定ヘルパーT細胞の発達にはCD8は必要ありません.
- この研究は,T細胞サブセットの分化と機能におけるCD8の特定の役割を明らかにしています.
関連する概念動画
Nephrotic Syndrome I : Introduction
476
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
476
Glomerular Filtration
4.7K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
4.7K
Renal Corpuscle
6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
Confocal Fluorescence Microscopy
19.9K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
19.9K
Nephrons
6.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.3K
Glomerular Filtration Rate and its Regulation
5.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.0K