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Updated: Aug 3, 2026

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids
10:32

On-chip Isotachophoresis for Separation of Ions and Purification of Nucleic Acids

Published on: March 2, 2012

関連ピューリンヌクレオシドフォスフォリレーゼによる移行状態のアナログ差別

Erika A Taylor Ringia1, Peter C Tyler, Gary B Evans

  • 1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Journal of the American Chemical Society
|June 1, 2006
PubMed
まとめ

移行状態のアナログであるImucillinsとDADMe-Immucillinsは, purin nucleoside phosphorylase (PNP) 酵素のために設計されました. 移行状態の幾何学を模倣することで,人間のPNPと牛のPNPの活性部位が保存されているにもかかわらず,結合親和性を成功裏に区別することができました.

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