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Updated: Jun 26, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

タンパク質-リガンド NOE マッチング:タンパク質NMR共振配分を必要としない結合ポーズ評価のための高スループット方法

Keith L Constantine1, Malcolm E Davis, William J Metzler

  • 1Bristol Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543, USA. keith.constantine@bms.com

Journal of the American Chemical Society
|June 1, 2006
PubMed
まとめ

この研究は,タンパク質 NMR 割り当てを必要とせずに,核オーバーハウザー効果 (NOE) データを使用して,タンパク質-リガンド結合ポーズを決定するための新しい方法を導入しています. このアプローチは,リガンド NMR 割り当てのみに依存することで,構造生物学を簡素化します.

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