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Updated: Jul 16, 2026

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

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メラトニンに対する遅延睡眠相症候群の反応

M Dahlitz¹, B Alvarez, J Vignau

¹Department of Neurology, King's College School of Medicine and Dentistry, University of London, UK.

Lancet (London, England)

|May 11, 1991

まとめ

メラトニンは,遅延睡眠相症候群の個体において,睡眠と目覚めの時間を大幅に改善しました. この研究は,メラトニンが睡眠覚醒サイクルのフェーズセットとして作用することを示唆しています.

科学分野:

クロノバイオロジークロノバイオロジー
スリープ・メディシン (睡眠医学)

背景:

遅延睡眠相症候群 (DSPS) は,通常の時間帯で眠りにつくことと目覚めることの持続的な困難によって特徴づけられる昼夜リズム障害です.
睡眠覚醒サイクルを調節するホルモンであるメラトニンは,昼夜リズム障害における治療的可能性のために調査されています.

研究の目的:

遅延睡眠相症候群と診断された被験者の睡眠覚醒サイクルに対するメラトニンの影響を調査する.
メラトニンの投与がDSPS患者の睡眠開始と目覚めの時間を早めることができるかどうかを判断する.

主な方法:

ランダム化,ダブルブラインド,プラセボ対照試験は,DSPSを持つ8人の被験者を対象に実施されました.
被験者は4週間にわたってメラトニン (毎日5mg) またはプラセボを投与され,1週間の洗浄期間が設けられました.
メラトニンまたはプラセボは,被験者の通常の睡眠開始時間より5時間前の22:00時に投与されました.

主要な成果:

メラトニン治療は,プラセボ (p <0.01) と比較して,睡眠開始時間 (平均82分) と覚醒時間 (平均117分) の両方を大幅に改善しました.
メラトニン治療中の平均総睡眠時間は,プラセボ (8時間46分) と比較して (8時間12分) わずかに短縮されました.
覚醒期アクロファゼは,ピーク覚醒のタイミングの指標であり,メラトニン治療では変化しませんでした.

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結論:

メラトニンの投与は,睡眠相遅延症候群を患っている人の睡眠と目覚めの時間を効果的に前進させます.
この発見は,DSPSにおける睡眠覚醒サイクルにおけるフェーズセッティング剤としてのメラトニンの役割を支持しています.
メラトニンは睡眠時間を促進しますが,睡眠時間と目覚めのタイミングに及ぼす影響については,さらなる調査が必要です.