系統性血管炎の治療には,静脈注射の免疫グロブリンを併用する

D R Jayne¹, M J Davies, C J Fox

¹Department of Medicine, School of Clinical Medicine, University of Cambridge, UK.

Lancet (London, England)

|May 11, 1991

まとめ

高用量静脈注射免疫グロブリン (IVIg) 治療は,全身性血管炎の患者で有意な臨床改善を示した. この治療は,疾患の活動と循環中の抗中性子細胞プラズマ抗体 (ANCA) を効果的に減少させました.

科学分野:

免疫学免疫学とは
レウマトロジーの病理学
内科内科は,内科の内科である.

背景:

システミック血管炎は,血管の炎症によって特徴付けられます.
従来の免疫抑制薬は,一部の患者では不十分かもしれません.
抗中性子細胞プラズマ抗体 (ANCA) は,しばしば血管炎の病原性に関与しています.

研究の目的:

高用量プールの静脈注射免疫グロブリン (IVIg) の治療効果を評価する.
系統性血管炎におけるIVIgの疾患活動とANCAレベルへの影響を評価する.

主な方法:

系統性血管炎の患者7人のコホートは,高用量IVIg.で治療されました.
患者には,免疫抑制および治療先の未経験の患者を含む,活性疾患を有する患者が含まれていました.
臨床的改善,ANCA濃度,およびC反応性タンパク質レベルをモニターした.

主要な成果:

7人の患者全員が臨床改善を経験し,6.6で持続しました.
平均ANCA濃度は51%減少し,フォローアップ期間中に低いままでした.
C反応性タンパク質濃度の大幅な低下が観察されました.

結論:

高用量IVIgは,全身性血管炎に対して有益な治療効果を提供します.
IVIg治療は安全で,このシリーズで報告された副作用はありません.
IVIgは,ANCAに関連した血管炎の治療に貴重な追加となる可能性があります.

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