1957年A2型インフルエンザ流行に産前感染した後の統合失調症
E O'Callaghan1, P Sham, N Takei
1Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Lancet (London, England)
|May 25, 1991
まとめ
1957年のインフルエンザ流行は統合失調症のリスクを増やす可能性がある. 流行のピークから5ヶ月後の出産では,後に統合失調症と診断された個人が88%増加しました.
科学分野:
- 神経科学は神経科学である.
- エピデミオロジー エピデミオロジー
- 精神科医は精神病を患っている.
背景:
- 統合失調症の病原性は複雑で,遺伝的および環境的要因が関与しています.
- 産前曝露は,神経発達障害の潜在的要因としてますます認識されています.
- 1957年のインフルエンザA2 (アジアインフルエンザ) パンデミックは,脳の発達に及ぼす環境の影響を研究するためのユニークな歴史的イベントを提供します.
研究 の 目的:
- 1957年のインフルエンザA2流行と,その後の統合失調症の発症との潜在的な関連を調査する.
- 疫病の影響を受けた特定の出生コホートがあったかどうかを判断するために.
主な方法:
- 統合失調症の入院患者の出生日付を遡及的に分析し,イングランドとウェールズの8つの保健地域を対象としたものです.
- 1957年のインフルエンザ流行のピーク後の期間の出生率とコントロール期間の出生率の比較.
主要な成果:
- 後に統合失調症を発症した人の出産が88%増加したのは,1957年のA2型インフルエンザ流行のピーク発生から5ヶ月後のことです.
- この発見はヘルシンキの出産データと一致し,既存の臨床的および神経病理学的証拠を裏付けています.
結論:
- 1957年のインフルエンザA2流行は,統合失調症の重要な環境リスク因子である可能性がある.
- 産前においてインフルエンザに曝された胎児の異常な脳の発達は,統合失調症の病原性における重要なメカニズムである可能性がある.
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