モルフォゲン産生と運動の調節による臓器の大きさのホックスの制御

Michael A Crickmore¹, Richard S Mann

¹Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

Science (New York, N.Y.)

|June 3, 2006

まとめ

ドロソフィラ・ウルトラビトラックス (Ubx) 遺伝子は,デカペンタプレジック (Dpp) 形態遺伝子を制御することによって,ハルテールサイズを制限します. Ubx は Dpp を制限しています.

科学分野:

発達生物学発達生物学とは
遺伝学遺伝学とは
分子生物学は分子生物学である.

背景:

セレクター遺伝子は,動物の身体部分の発達を指揮する.
セレクター遺伝子が臓器のサイズに影響を与えるメカニズムは不明である.
ドロソフィラ・ウルトラビトラックス (Ubx) 遺伝子は,重要なセレクター遺伝子である.

研究の目的:

Ubx遺伝子がドロソフィラのハルテールサイズをどのように調節するかを調査する.
Ubx媒介型サイズ制御の基礎となる分子メカニズムを解明する.

主な方法:

ドロソフィラのハルテールと翼のイメージナルディスクにおける遺伝子発現とタンパク質の局所化の分析.
デカペンタペリジック (Dpp) 信号経路の役割を調査する.
UbxとDPP受容体の相互作用を研究する.

主要な成果:

Ubxは,翼と比較してハルテアのサイズを大幅に制限し,細胞が少なくなります.
Ubxは,DPPの転写とDPPの移動性を抑制することによって,ハルテールサイズを制限します.
Ubxは,DPP受容体の発現を増加させ,DPPの分布を制限します.

結論:

Ubxのようなセレクター遺伝子は,形態遺伝子の活動を調節することによって,臓器のサイズを制御することができます.
Ubx-Dppの相互作用は,大きさの違いを達成するために発達経路がどのように変更されるかのモデルを提供します.
このメカニズムは,動物の発達におけるサイズ規制のための潜在的に一般的な戦略を提供します.

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