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Updated: Jul 17, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

遺伝性ALSの発症と進行は,運動ニューロンとマイクログリアによって決定されます

Séverine Boillée1, Koji Yamanaka, Christian S Lobsiger

  • 1Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Science (New York, N.Y.)
|June 3, 2006
PubMed
まとめ

スーパーオキシドディスミュータゼにおける支配的な変異は,アミオトロフィック横筋硬化症 (ALS) を引き起こします. モーターニューロンの変異遺伝子の発現は早期の病気を誘発し,マイクログリアの関与は後の進行を遅らせ,細胞ベースの治療法を検証する.

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