料金信号を整理する
Katherine A Fitzgerald1, Zhijian J Chen
1Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. kate.fitzgerald@umassmed.edu
Cell
|June 6, 2006
まとめ
TIRAP/Malのようなトール型受容体アダプターは,プラズマ膜でPIP2と結合する. この相互作用は,MyD88をToll型受容体4に誘導し,免疫信号伝達とフォスフォリピド代謝を結びつける上で極めて重要です.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- トール型受容体 (TLR) は,生来の免疫システムの重要な構成要素であり,微生物の産物を認識します.
- TLRの活性化は,特定の遺伝子発現を誘発するために,アダプタータンパク質を含む細胞内シグナリングカスケードを誘発します.
- 異なるTLRは異なるアダプタを勧誘し,TLR特異の免疫反応を引き起こします.
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