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Updated: Jul 19, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors

Published on: July 17, 2020

PPM1Aは,TGFβシグナル伝達を終了するSmadファスファターゼとして機能します

Xia Lin1, Xueyan Duan, Yao-Yun Liang

  • 1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. xialin@bcm.edu

Cell
|June 6, 2006
PubMed
まとめ

タンパク質フォスファタゼ1A (PPM1A) は,Smad2/3を脱酸化し,その核輸出を促進し,TGFβシグナル伝達を終了させます. このフォスファテーゼは,がんや線維症を含む重要な発達と疾患の経路を調節します.

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Published on: October 27, 2020

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay11:38

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Published on: September 14, 2021

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