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Updated: May 2, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

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TGFβ経路の異なるTIF1gammaとSmad4分岐によって制御される血液形成

Wei He1, David C Dorn, Hediye Erdjument-Bromage

  • 1Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Cell
|June 6, 2006
PubMed
まとめ

転写中間因子1gamma (TIF1gamma) はSmad4と競合してSmad2/3を結合し,細胞運命を左右する. この相互作用により,TGFβシグナル伝達に反応して,Smad2/3-TIF1gammaとSmad2/3-Smad4経路が形成されます.

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

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Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

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General Transcription Factors

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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