鎮痛剤を乱用する片頭痛患者における薬剤の突然の室外離脱
1Princess Margaret Migraine Clinic, Charing Cross Hospital, London, UK.
Lancet (London, England)
|June 15, 1991
まとめ
慢性的な毎日の頭痛の患者で痛みを和らげる薬を突然撤回すると,片頭痛の薬物の過剰使用が効果的に減少しました. ほとんどの患者は6ヶ月以内に頭痛の緩和を経験し,鎮痛剤の使用が正常化しました.
科学分野:
- 神経学 神経学とは
- 薬理学 薬理学とは
背景:
- 薬の過剰使用は,片頭痛患者の慢性的な毎日の頭痛の一般的な原因です.
- 薬物乱用の特定と治療は,慢性頭痛障害の管理に不可欠です.
研究 の 目的:
- 片頭痛患者における薬物乱用による二次的な慢性日々の頭痛の治療における突然の薬物離脱の有効性を評価する.
- この治療戦略の長期的な成果を評価する.
主な方法:
- 薬物乱用による慢性的な毎日の頭痛を有する46人の片頭痛患者が登録されました.
- 治療には,突然の薬物離脱,患者教育,定期的なフォローアップ,アミトリプチリン,ナプロクセンによる症状緩和が含まれていました.
主要な成果:
- 46人の患者のうち37人 (80%) が慢性頭痛の緩和を達成し,6ヶ月後に鎮痛剤の摂取量を正常化しました.
- 6人の患者は鎮痛剤の摂取量が減ったが,頭痛の重度の変化はなかった.
- 2人の患者は摂取量を減らさなかったし,1人の患者は研究から撤退した.
結論:
- 補助ケアと適切な薬剤療法と組み合わせた有害な薬剤の突然の離脱は,薬物の過剰使用による片頭痛患者の慢性的な毎日の頭痛の効果的な治療法です.
- このアプローチは,頭痛を大幅に軽減し,薬物使用の正常化につながる可能性があります.
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