抗利尿性ペプチド (DDAVP) の投与は,脱皮質化した皮膚を吸い込む方法によるものです
P Svedman1, S Lundin, C Svedman
1Department of Plastic and Reconstructive Surgery, University of Lund, Malmö, Sweden.
Lancet (London, England)
|June 22, 1991
まとめ
無痛な表皮の除去を含む新しい皮膚経由薬剤投与方法により,1-デアミノ-8-D-アルギニンバソプレシン (DDAVP) の100%の生物利用性が達成されました. このテクニックは,繰り返し使用しても,効果的な薬物の吸収を約束しています.
科学分野:
- 薬理学 薬理学とは
- 皮膚科 皮膚科について
- バイオメディカルエンジニアリング
背景:
- エピダーミスは,皮膚経由の薬剤投与に重大な障壁を提示しています.
- 皮膚経由での完全かつ予測可能な薬物の吸収を達成することは,依然として課題です.
研究 の 目的:
- エピダーミスの除去を含む新しい皮膚経由の薬剤投与方法を評価する.
- この方法を使用して,1-デアミノ-8-D-アルギニンバソプレシン (DDAVP) の生物利用性と有効性を評価する.
主な方法:
- 前腕の表面皮の小さな領域 (直径5mm) は,真空装置を使用して無痛に除去されました.
- DDAVPは,非エピテリア化された部位に施されたオクラシブ貯水池を通して投与されました.
- プラズマのDDAVP濃度は,レーザードップラー流量測定を用いて,時間の経過とともにモニタリングされました.
主要な成果:
- プラズマのDDAVP濃度は,ゼロ順位の動力学に従っており,静脈注入と比較できる100%近くの生物利用性を示しています.
- 4日間毎日繰り返し投与すると,皮膚の再表皮化に障害がないことが示されました.
- 血のDDAVP濃度は,糖尿病の治療用濃度を超えました.
結論:
- 無痛な真空アシストされた表皮除去は,皮膚経由の薬物投与のための効果的な方法です.
- この技術は,DDAVPのような薬剤に高い生物利用性と治療的可能性を提供します.
- 誘発性皮膚高血症は,薬の浸透を高め,6週間以内に皮膚が正常に戻る可能性があります.
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