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Updated: Jul 19, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

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形式化ドメイン: 線形グラミシジニンの非リボソーム生物合成のための重要な修飾酵素

Georg Schoenafinger1, Nadine Schracke, Uwe Linne

  • 1Fachbereich Chemie/Biochemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, D-35032 Marburg, Germany.

Journal of the American Chemical Society
|June 8, 2006
PubMed
まとめ

この研究は,非リボソーム性ペプチド合成酵素LgrA1.1によるグラミシジン生物合成の開始にN型化が不可欠であることを明らかにしています. 形式化ドメインは,ホルミール基をバリンに転送し,ペプチド鎖の延長に必要なスタートユニットを作成します.

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