神経頂部の発達と喉の進化におけるSoxEの重要性
David W McCauley1, Marianne Bronner-Fraser
1Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. dwmccauley@ou.edu
Nature
|June 9, 2006
まとめ
海のニューラルクライストの発達は,脊椎動物の進化における保存されたSoxE遺伝子の機能を明らかにする. これらの遺伝子は頭蓋骨の発達に不可欠であり,枝状の弧を形成する古代の役割を強調しています.
科学分野:
- 進化的発達生物学 進化的発達生物学
- 比較ゲノミクスとは
- 脊椎動物の古生物学について
背景:
- ニューラル・クライストは脊椎動物の革新であり,頭蓋骨顔面の発達に不可欠である.
- SoxE遺伝子 (Sox8, Sox9, Sox10) は,のある脊椎動物における神経頂部発達の主要な調節体である.
- 基礎脊椎動物におけるSoxE機能を理解することで,神経頂部の進化に光を当てることができます.
研究 の 目的:
- 海の (Petromyzon marinus) の頭蓋の発達におけるSoxE遺伝子の役割を調査する.
- 脊椎動物の枝状弓の発達におけるSoxE遺伝子機能の進化的起源を追跡する.
主な方法:
- 海の胚におけるSoxE遺伝子の発現パターンを分析した.
- SoxE1の機能を評価するために,Morpholino媒介の遺伝子ノックダウンを使用しました.
- 頭蓋の顔面と枝状の弓の発達を調べました.
主要な成果:
- 2つのSoxE遺伝子は,ニューラルクライストの移動とブランキアルークの発達で発現しています.
- SoxE1のノックダウンは,後部枝状の弓の発達を妨害するが,下の弓の発達を阻害しない.
- SoxE遺伝子は,枝状アーチ内のコンドロゲネシスに不可欠な役割を果たします.
結論:
- SoxEレギュレータのコンドロゲン機能は,ランプレイ-グナトストームの共通の祖先から保存されています.
- Lamprey SoxE遺伝子は,独立した重複を経験し,特化した機能につながった可能性があります.
- この研究は,脊椎動物の枝状弓の同質性とその進化的起源についての洞察を提供します.
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