高齢者におけるフィブリノゲン濃度の季節的変動
1Department of Geriatric Medicine, Queen's University of Belfast, UK.
Lancet (London, England)
|July 6, 1991
まとめ
高齢者は,プラズマフィブリノゲン (血液凝固タンパク質) の季節的な変化のために,冬に心臓血管疾患のリスクが高くなります. 低体温と環境温度はフィブリノゲンを増加させ,心臓発作や脳卒中の可能性を高めます.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 心血管医学 心血管医学
- 環境衛生 環境衛生 環境衛生
背景:
- 高齢者集団は,冬季中に死亡率と罹病率の増加を示しています.
- 致命的および非致命的な心筋梗塞および脳卒中率の両方で季節的な変動が観察されています.
- 高齢者の冬の多発性心血管疾患に寄与する要因を特定することは極めて重要です.
研究 の 目的:
- 冬の間,高齢者の心血管疾患の発生率の増加に寄与する要因を調査する.
- 高齢者の心血管疾患のリスク因子の季節的変動を調べる.
主な方法:
- 75歳以上,様々な宿泊施設に居住する100人の参加者を対象とした縦断的な研究.
- 体温と環境温度を毎月モニタリングし,1年間にわたって心血管リスク要因を測定します.
- フィブリノゲン,血粘度,およびHDLコレステロールに対する季節的な影響の分析.
主要な成果:
- 線維素素,血粘度,およびHDLコレステロール (p < 0.003) に関する季節的な影響が顕著であった.
- プラズマ線維原素濃度は,夏と比べて冬に23%高く,体温や環境温度と負の相関関係があった.
- 施設内の個人は,コミュニティの住民よりもプラズマ線維素素の変動が大きいことを示しました.
結論:
- プラズマフィブリノゲン濃度の大幅な季節的変動は,冬の間,高齢者の心筋梗塞と脳卒中のリスクを大幅に高めます.
- 周囲の温度や体温は,血のフィブリノゲン濃度に影響するようです.
- 生活の条件 (施設 vs. コミュニティ) は,季節的なフィブリノゲン変化に影響を与える可能性があります.
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