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Updated: Jul 17, 2026

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Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
PUVAと癌:大規模な疫学研究
B Lindelöf1, B Sigurgeirsson, E Tegner
1Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Lancet (London, England)
|July 13, 1991
まとめ
皮膚疾患に対するポサラレンと紫外線A放射線 (PUVA) 治療は,がんのリスクを増やす可能性があります. スウェーデンの研究では,特に200以上の治療法で,状細胞がんの投与量に依存する増加が確認されました.
科学分野:
- 皮膚科 皮膚科について
- 腫瘍学 腫瘍学
- フォトセラピーの研究
背景:
- プソラレンおよび紫外線A放射線 (PUVA) 療法による長期的な発がん性影響に関する懸念があります.
- PUVAは,様々な皮膚疾患の一般的な治療法です.
研究 の 目的:
- PUVA療法と特定の癌を発症するリスクとの関連を調査する.
- PUVA治療とがん発生率の投与量依存関係を評価する.
主な方法:
- 1974年から1985年の間にPUVAで治療を受けた4799人のスウェーデン人の患者のコホート研究.
- 受けたPUVA治療の数と患者の人口統計と関連して,がん発生率の分析.
- 追跡期間は,平均して男性6.9年,女性7.2年であった.
主要な成果:
- 皮膚の状細胞がんのリスクの有意な用量依存の増加が観察されました.
- 200回以上のPUVA治療を受けた男性患者は,一般の人々と比較して,状細胞がんの発生率が30倍以上の増加を示しました.
- 呼吸器がん (男性および女性),臓がん (男性),腎臓および結腸がん (女性) の高発症率も認められた (p <0.05).
結論:
- この研究は,PUVA療法後の状細胞がんの発生率の投与量依存の増加を確認しています.
- PUVA治療は,他のいくつかの癌のリスクを高めることに関連しており,さらなる調査と慎重な患者の選択を正当化しています.
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