低濃度のオゾンが,喘息患者における吸入アレルゲン反応に与える影響
N A Molfino1, S C Wright, I Katz
1Department of Medicine, University of Toronto, Ontario, Canada.
Lancet (London, England)
|July 27, 1991
まとめ
低レベルのオゾンへの曝露は,喘息患者におけるアレルゲンに対する呼吸道反応を著しく増加させる. 喘息の症状に対するオゾン効果は,肺機能のベースラインを変化させない.
科学分野:
- 環境衛生 環境衛生 環境衛生
- 肺医学 肺医学について
- アレルギー 免疫学
背景:
- オゾンとアレルゲンは両方とも呼吸道炎症を引き起こし,潜在的に喘息に影響を与える可能性があります.
- 周囲のオゾンとアレルギー反応の相互作用を理解することは,喘息の管理に不可欠です.
研究 の 目的:
- 低レベルのオゾン被曝が喘息患者の呼吸道アレルギー反応を強めるかどうかを調査する.
- オゾンが,吸入されたアレルゲンに対する支氣管の反応に影響するかどうかを判断する.
主な方法:
- 7人のアトピー性喘息患者は,メタコリンチャレンジとアレルゲン吸入検査を受けた.
- 被験者は,アレルゲンまたはプラセボを吸入する1時間前に,空気または0.12ppmオゾンに暴露されました.
- 呼吸道反応性は,FEV1 (PC15) を15%低下させるのに必要なアレルゲンの濃度で測定されました.
主要な成果:
- オゾンへの曝露は,1秒間の強制排気量 (FEV1) のベースラインを有意に変化させなかった.
- PC15はオゾン吸入に続いてアレルゲンを摂取した後に有意に減少し,反応性の向上を示した (PC15の平均値は,オゾン吸入後の0.0056 mg/mlと空気吸入後の0.013 mg/ml).
結論:
- 都市部で多い低レベルのオゾン曝露は,アトピー性喘息患者におけるアレルゲンに対する支氣管の反応性を高めます.
- オゾンによるアレルギー反応の強化は,ベースラインの呼吸道機能の変化なしに起こります.
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