新生児における心血管自律機能不全の証拠は,大動脈の縮を伴う
Jaimie W Polson1, Naomi McCallion, Hidefumi Waki
1Department of Clinical Sciences at South Bristol, School of Medical Sciences, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom.
Circulation
|June 14, 2006
まとめ
大動脈縮 (CoA) の新生児は,高血圧と低気力反射感受性を含む異常な自律性心血管機能を示します. これらの初期の自律的変化は,後の高血圧リスクに寄与する可能性があります.
科学分野:
- 心血管生理学 心血管の生理学
- 新生児医学 新生児医学
- 自律神経系の機能 自律神経系の機能
背景:
- 大動脈の (CoA) は,修復後の持続的な高血圧と血圧制御の問題と関連しています.
- CoAの新生児修復は,後の血圧異常を防ぐことはできませんでした.
- 自律性心血管機能の早期の病理的調整は,CoAを持つ新生児に起こり得る.
研究 の 目的:
- 動脈大動脈の収縮を患っている新生児が,自律性心血管機能不全の早期徴候を示すかどうかを調査する.
- 新生児の自律性心血管機能を,健康な新生児と比較するために.
主な方法:
- 単純なCOAを投与した新生児8人と,健康な対照群13人を研究した.
- ECGとシーケンスメソドロジーを使用して,自発的なバロレフレクスの感受性を測定しました.
- 非侵襲的血圧モニタリングを使用して,心拍数変動 (時間および周波数領域) と血圧変動 (周波数領域) を評価.
主要な成果:
- CoAを患った新生児は,対照群と比較して高血圧 (78.9対67.1 mm Hg) であった.
- CoAの乳児は,抑うつされたバロレフレクスの感度 (8.7 vs. 13.8 ms/mm Hg) と心拍の変動性の低下 (16.5 vs. 31.5 ms2) を示した.
- 血圧変動の高周波成分の増加は,CoA (3.1対2.2mmHg2) を有する新生児で観察されました.
結論:
- 大動脈の縮を患った乳児は,自律性心血管ホメオスタシスの病理的調整を示します.
- これらの発見は,COAを持つ新生児の自律的変化が,後の高血圧に先行する可能性があることを示唆しています.
- これらの変化が高血圧を発症するリスクにおける役割を確認するために,さらなる縦断研究が必要である.
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