メタボリック障害は, rhesus macaques のシミアン免疫不全ウイルス感染の早期の結果である
H P Eck1, C Stahl-Hennig, G Hunsmann
1Deutsches Krebsforschungszentrum, Institute of Immunology and Genetics, Heidelberg, Germany.
Lancet (London, England)
|August 10, 1991
まとめ
HIV-1患者における高血グルタミン酸と低チオールのレベルは,レトロウイルス感染症の早期の結果である. マカクのモデルでは,これらの変化が猿の免疫不全ウイルス感染後に急速に発生することを示しました.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 神経化学 神経化学とは
- 免疫学 免疫学とは
背景:
- 以前の研究では,HIV-1患者の血グルタミン酸濃度が高く,チオール濃度が低いことが示されました.
- HIV-1感染の原因または結果としてこれらの生化学的変化の役割は不明のままでした.
研究 の 目的:
- 血グルタミン酸およびチオール濃度の変化がHIV-1感染の結果または危険因子であるかどうかを判断する.
- 関連する動物モデルでこれらの生化学的変化を調査する.
主な方法:
- rhesus macaqueとfascicularis macaqueのシミアン免疫不全ウイルス (SIVmac251) 感染モデルを利用した.
- 23匹の感染したマカクと18匹の感染していない対照群の血グルタミン酸とチオール濃度を比較した.
主要な成果:
- 感染したマカクは,血のチオールの平均濃度 (p < 0.001) を著しく低下させた.
- 感染したマカクは,プラズマグルタミン酸平均濃度 (p <0.001) を著しく高めた.
- これらの生化学的変化は,感染後1週間ほどで検出されました.
結論:
- 異常な血グルタミン酸およびチオール濃度は,このマカクのモデルにおけるレトロウイルス感染症の直接的および早期の結果である.
- 研究結果は,これらの生化学的変化が危険因子ではなく,感染そのものの結果であることを示唆しています.
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