関連する実験動画

Updated: Jun 13, 2026

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells
10:24

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells

Published on: December 17, 2012

異変したmRNAを細胞プラズマの処理体に標的とする

Ujwal Sheth1, Roy Parker

  • 1Department of Molecular and Cellular Biology, University of Arizona, Tucson, 85721, USA.

Cell
|June 17, 2006
PubMed
まとめ

酵母菌における無意味媒介性腐敗 (NMD) は,欠陥のあるmRNAを分解のためにP体へと標的とする. Upf1pのような特定のタンパク質は,このターゲティングとその後のmRNAの分解を容易にし,異常と正常のトランスクリプトを区別します.

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...